The Pittsburgh Pirates visit Wrigley Field to take on the Chicago Cubs on June 14th, 2025, at 2:20 PM. The Cubs are favored with a moneyline of -228, while the Pirates sit at +187. Both teams have had their ups and downs, with the Pirates holding a record of 28-42 and the Cubs at 42-27. For the latest betting odds, check out The Edge AI sports betting tool for the best bets. Key players to watch include Isiah Kiner-Falefa for the Pirates, who has a .297 batting average and 1 home run, and Nico Hoerner for the Cubs, hitting .285 with 29 RBIs. Andrew McCutchen also adds depth to the Pirates lineup with a .755 OPS. No significant injuries are reported for either team, which should keep both squads at full strength. In their recent matchup history, the Cubs have had the upper hand, winning two of the last three encounters.